The crystal structure of glycogen phosphorylase in complex with 20
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The crystal structure of glycogen phosphorylase in complex with 20 Descriptor: 2-(4-fluorophenyl)-5,7-bis(oxidanyl)chromen-4-one, Glycogen phosphorylase, muscle form Authors: Kyriakis, E, Koulas, S.M, Skamnaki, V.T, Leonidas, D.D. Deposit date: 2020-02-25 Release date: 2020-08-19 Last modified: 2025-04-09 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. Bioorg.Chem., 102, 2020
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2020-02-25
