Data for the manuscript "Bridged Nucleic Acid ASOs over Locked Nucleic Acid ASOs and their impact on the structure and stability of ASO/RNA duplexes"

Data for the manuscript "Bridged Nucleic Acid ASOs over Locked Nucleic Acid ASOs and their impact on the structure and stability of ASO/RNA duplexes". The dataset contains: <strong>Table 1: </strong>Co-ordinates of optimized structures of LNA; N-MeO-amino-BNA; 2′,4′-BNA^NC[NH]; 2′,4′-BNA^NC[NMe] and N-Me-aminooxy-BNA monomer nucleotides without the phosphate backbone each containing nucleobases Adenine (A), Guanine (G), 5-Methylcytosine (C) and Thymine (T) calculated at the M06-2X/6-311G(d,p) level of theory. <strong>Table 2: </strong>Co-ordinates of optimized structures of LNA; N-MeO-amino-BNA; 2′,4′-BNA^NC[NH]; 2′,4′-BNA^NC[NMe]; N-Me-aminooxy-BNA monomer nucleotides and PS-LNA; PS-N-MeO-amino-BNA; PS-2′,4′-BNA^NC[NH]; PS-2′,4′-BNA^NC[NMe]; PS-N-Me-aminooxy-BNA monomer nucleotides (R &amp; S conformers) each containing nucleobases Adenine (A), Guanine (G), 5-Methylcytosine (C) and Thymine (T) calculated at the M06-2X/6-311G(d,p) level of theory. <strong>Table 3: </strong>Frcmod files of LNA; N-MeO-amino-BNA; 2′,4′-BNA^NC[NH]; 2′,4′-BNA^NC[NMe]; N-Me-aminooxy-BNA monomer nucleotides and PS-LNA; PS-N-MeO-amino-BNA; PS-2′,4′-BNA^NC[NH]; PS-2′,4′-BNA^NC[NMe]; PS-N-Me-aminooxy-BNA monomer nucleotides (R &amp; S conformers) each containing nucleobases Adenine (A), Guanine (G), 5-Methylcytosine (C) and Thymine (T) optimised at the M06-2X/6-311G(d,p) level of theory. <strong>Table 4:</strong> Library files of LNA; N-MeO-amino-BNA; 2′,4′-BNA^NC[NH]; 2′,4′-BNA^NC[NMe]; N-Me-aminooxy-BNA monomer nucleotides and PS-LNA; PS-N-MeO-amino-BNA; PS-2′,4′-BNA^NC[NH]; PS-2′,4′-BNA^NC[NMe]; PS-N-Me-aminooxy-BNA monomer nucleotides (R &amp; S conformers) each containing nucleobases Adenine (A), Guanine (G), 5-Methylcytosine (C) and Thymine (T) optimised at the M06-2X/6-311G(d,p) level of theory.