Mn(I)-Catalyzed Site-Selective C–H Activation: Unlocking Access to 3‑Arylated Succinimides from 2‑Arylpyridines and Maleimides

An efficient and cost-effective Mn(I)-catalyzed site-selective C–H activation of 2-arylpyridines with maleimides has been described. This approach facilitates the synthesis of 3-arylated succinimide derivatives with high site selectivity, chemoselectivity, catalytic efficiency, and outstanding tolerance to numerous functional groups. The practicality of this approach is further evidenced by its successful application in large-scale reactions and the conversion of the synthesized succinimide derivatives into other valuable compounds.