In vitro activities of compounds 1–5, CQ, and AQ against CQ-sensitive and CQ-resistant strains of P. falciparum.

IC50 ± SD values (nM) determined from independent experiments performed in triplicate in two laboratories (A, Marseille; B, Paris) under different assay conditions (see main text and Materials and Methods Section for details). CQ: chloroquine, AQ: amodiaquine, -: not determined.bNote that Dd2 is CQ-resistant under the culture conditions of laboratory A and CQ-sensitive under the culture conditions of laboratory B.In vitro activities of compounds 1–5, CQ, and AQ against CQ-sensitive and CQ-resistant strains of P. falciparum.