Targeting the protein–protein interaction between p53 and MDM2/MDMX (MDM4) represents an attractive anticancer strategy for the treatment of p53-competent tumors. Several selective and potent MDM2 inh

Figshare2018-10-10 更新60

Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction

蛋白质-蛋白质相互作用抑制剂

小分子药物

Identification of low-dose, low-molecular-weight, drug-like inhibitors of protein–protein interactions (PPIs) is a challenging area of research. Despite the challenges, the therapeutic potential of PP

Figshare40

Virtual and Biophysical Screening Targeting the γ-Tubulin Complex – A New Target for the Inhibition of Microtubule Nucleation

抗癌药物靶点研究

蛋白质-蛋白质相互作用抑制剂

Microtubules are the main constituents of mitotic spindles. They are nucleated in large amounts during spindle assembly, from multiprotein complexes containing γ-tubulin and associated γ-tubulin compl

Figshare2016-01-18 更新60

Cell-Penetrant Peptides as Novel Inhibitors of the Interaction of Coatomer Protein COPB2/RACK2 with Protein Kinase Cε and Cargo Proteins

糖尿病分子机制

蛋白质-蛋白质相互作用抑制剂

Type 2 Diabetes Mellitus (T2DM) is a multifactorial metabolic disorder characterised by insulin resistance and defective insulin secretion. The lipid-activated novel protein kinase C isoform, PKCε, ha

NIAID Data Ecosystem50

Inhibition potencies of the p27-KID mutants.

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