Metadata record for the manuscript: Clinical behavior and outcomes of breast cancer in young women with germline BRCA pathogenic variants

Summary

This
metadata record provides details of the data supporting the claims of the
related manuscript: “Clinical behavior and outcomes of
breast cancer in young women with germline BRCA pathogenic variants”.

The
related study aimed to determine the impact of type of gene (BRCA1 vs. BRCA2)
and hormone receptor status (positive [HR+] vs. negative [HR-]) on clinical behaviour
and outcomes of mBRCA (germline BRCA pathogenic variant) breast cancer.

Type of data:
international, multicenter, hospital-based, retrospective cohort study.

Subject of
data: homo sapiens: young breast
cancer (BC) patients carrying a germline BRCA
pathogenic variant (mBRCA).

Sample size:
1236.

Population
characteristics: women diagnosed at age ≤ 40 years with invasive early breast
cancer (stage I-III) between January 2000 and December 2012. All included
patients had a known germline BRCA1 or BRCA2 pathogenic variant.

Data
access

The data
generated and analysed during the related study are stored in the following
four Excel spreadsheets: ‘Patient survival data.xlsx’, ‘Patient baseline, tumor
and treatment data.xlsx’, ‘Patient risk reducing surgery data.xlsx’, ‘Patient
eligibility criteria and survival data.xlsx’. These data are not publicly
available for the following reason: data contain
information that could compromise research participant privacy. However, the
data can be made available upon reasonable request to the corresponding author.
A list of which data file underlies which figure, table and supplementary table
in the related manuscript is provided in the file ‘Lambertini et al underlying
data lookup.csv’, included as part of this metadata record.

The
dataset analysed during this study is described with more details in the
following manuscript: https://doi.org/10.1200/JCO.19.02399.

Corresponding author(s) for this study

Matteo
Lambertini, MD PhD, IRCCS Ospedale Policlinico San Martino, University of
Genova, Largo Rosanna Benzi 10, 16132 – Genova (Italy), Telephone [phone]
4254 – Fax: [phone]. E-mail: [e-mail].

Study approval

The
Institut Jules Bordet (Brussels, Belgium) coordinated the study and acted as
central ethics committee. Ethics approval by the Institutional Review Boards of
participating centers and patients’ written informed consent were obtained
before inclusion whenever requested by local regulations.