Circulating PAI-1 during the post-CLP phase in post-traumatic sepsis versus sepsis alone.

Three week-old mice were subjected to trauma and hemorrhage (TH) followed by polymicrobial cecal ligation and puncture (CLP) sepsis or CLP alone (CLP-Only). At 0, 6, 12 and 24 h post-CLP, mice (n = 6 mice per time point) were sacrificed and blood was collected and analyzed for total plasminogen activator inhibitor type 1 (PAI-1) in plasma. Data as mean ± SD (TH-CLP and CLP-Only rows) representing 5–6 mice per time point. Fold PAI-1 difference between TH-CLP and CLP-Only.§Values obtained from a separate study (22).*P