Micro-RNAs from Plasma-Derived Small Extracellular Vesicles as Potential Biomarkers for Tic Disorders Diagnosis

tic disorders (TDs) are a series of childhood neuropsychiatric disorders characterized by invol-untary motor and/or vocal tics and commonly comorbid with several other psychopathological and/or behavioral disorders. In the present study, we aimed to identify serum small extracellular vesicles (sEVs) derived microRNAs (miRNAs) from the serum samples of children for Tic Disorders Diagnosis Expression of circulating miRNAs from serum sEVs between Tic Disorders and healthy children was assessed in this multiphase case-control study. Definitions: TTD: transient tic disorder CTD:chronic motor or vocal tic disorder TS:Tourette Syndrome HC: healty control