scRNA-seq analysis of CD11c+ cells from bronchoalveolar lavage fluid during the IAV (PR/8, H1N1) infection course

CX3CR1pos monocytes are mobilized upon infection and undergo monocyte-to-macrophage transition in inflamed tissues. Using scRNA-seq of CD11c+ cells from bronchoalveolar lavage fluid (BALF) infected with IAV (PR/8, H1N1 ,we demonstrate that, during severe viral pneumonia, bone marrow-derived macrophages (BMDM) pass co-ordinated trajectories of pro-inflammatory-to-tissue-healing phenotypes, before differentiating into tissue-resident alveolar macrophages, that retain a long-term tissue-protective phenotype. scRNA-seq analysis of CD11c+ cells from bronchoalveolar lavage fluid during the IAV (PR/8, H1N1) infection course