Foxl1

Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including Peyer's patch morphogenesis; proteoglycan biosynthetic process; and visceral mesoderm-endoderm interaction involved in midgut development. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in otosclerosis 11. Orthologous to human FOXL1 (forkhead box L1). [provided by Alliance of Genome Resources, Nov 2024]

激活 DNA 结合转录因子活性。在多个过程中发挥作用，包括派伊尔斑形态发生；蛋白聚糖生物合成过程；以及涉及中肠发育的脏层间充质-内胚层相互作用。预测该基因定位于细胞核。在多个结构中表达，包括消化系统；中枢神经系统；心脏；感觉器官；以及泌尿系统。该基因的人类同源基因与耳硬化症11有关。与人类 FOXL1（叉头框L1）同源。[由基因组资源联盟提供，2024年11月]

搜集汇总

背景与挑战

背景概述

Foxl1基因具有DNA结合转录因子活性，参与多个生物过程如Peyer斑块形态发生和蛋白聚糖生物合成过程，并在消化系统、中枢神经系统等多个器官系统中表达。该基因与人类FOXL1基因同源，并与人类耳硬化症11相关。