The STRIPAK complex regulates response to chemotherapy through p21 and p27
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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We report that loss of a component of the STRIPAK complex in MDA-MB-231 cells known as STRIP1 causes cell cycle arrest and decreased proliferation due to increased expression of cyclin dependent kinase inhibitors, p21 and p27. This change in p21 and p27 expression results in a subset of cells forgoing therapy-induced senescence and becoming proliferative.
提供机构：
Lund University
创建时间：
2022-02-20
