Efficacy and safety of corticosteroid regimens for the treatment of hospitalized COVID-19 patients: a meta-analysis: Supplementary data

Aim: To evaluate the efficacy and safety of corticosteroids for treating hospitalized COVID-19 patients.
Materials & methods: Efficacy outcomes included time to negative SARS-CoV-2 tests, length of
stay, duration and incidence of intensive unit care stay, incidence of mortality and duration and
incidence of mechanical ventilation. Safety outcomes included the incidence of adverse events and
severe adverse events, incidence of hyperglycemia and incidence of nosocomial infections. Results:
Ninety-five randomized controlled trials (RCTs) and observational studies (n = 42,205) were included.
Corticosteroids were associated with increased length of stay (based on RCT only), increased time
to negative tests, decreased length of mechanical ventilation and increased odds of hyperglycemia.
Conclusion: Corticosteroids should be considered in patients requiring mechanical ventilation, and
glycemic monitoring may be needed when administering corticosteroids.