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Stereospecific Copper-Catalyzed Domino Ring Opening and sp<sup>3</sup> C–H Functionalization of Activated Aziridines with <i>N</i>‑Alkylanilines

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NIAID Data Ecosystem2026-03-10 收录
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Copper efficiently catalyzed nucleophilic ring opening, sp3 C–H functionalization, and C–N bond formation in the presence of tert-butyl hydroperoxide to afford functionalized imidazolidines starting from N-sulfonylaziridines and N-alkylanilines. The products were obtained in high optical purities (95 → 99% ee) with excellent functional group tolerance.

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2016-12-15
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