Gene expression data from endometrial cancer patient-derived cells (EDC-PDCs) treated with Efp siRNA

To examine the role of Efp in endometrial cancer, patient-derived cells were treated with siRNA targeting Efp (siEfp) or control siRNA (siControl). siRNA-mediated Efp silencing resulted in suppressed spheroid proliferation and altered gene expression profile, featuring downregulation of genes related to cell cycle and inflammation/immune responses. This study provides an insight into alternative endometrial cancer therapeutic strategies targeting Efp. Total RNA was extracted from endometrial cancer patient-derived cells (EC-PDCs) treated with siRNAs targeting Efp (siEfp #A) or control siRNA (siControl) and then used for Affymetrix microarrays analysis.