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Ruthenium-Catalyzed Synthesis of <i>cis</i>-2,3-Dihydrobenzofuran-3-ols by Aqueous Transfer Hydrogenation via Dynamic Kinetic Resolution

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NIAID Data Ecosystem2026-03-10 收录
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The preparation of cis-2,3-dihydrobenzofuranols with two stereocenters through aqueous asymmetric transfer hydrogenation (ATH) of benzofuranones with the metal catalyst Ru­(II) via dynamic kinetic resolution (DKR) has been developed. A variety of α-alkyl benzofuranones were transformed to obtain optically pure 2,3-dihydrobenzofuran-3-ols with excellent enantioselectivities and acceptable yields under mild conditions.

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2017-03-27
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