Design of Stable β‑Hairpin Mimetics through Backbone Disulfide Bonds
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https://figshare.com/articles/dataset/Design_of_Stable_Hairpin_Mimetics_through_Backbone_Disulfide_Bonds/2215351
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资源简介：
The
synthesis and utilization of novel thiostatines (β-SH-substituted
γ-amino acids) in the design of backbone-disulfide-stabilized
β-hairpin mimetics, solution conformations of hybrid β-hairpins
and Cys-disulfide-stabilized α-peptide analogue, their thiol
exchange, and proteolytic stability are investigated. The results
suggest that thiostatines can be used to design proteolytically stable
water-soluble β-hairpin mimetics without deviating from overall
β-hairpin conformation.
创建时间：
2016-02-16
