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A novel animal model for secondary progressive multiple sclerosis by oligodendroglia-specific conditional connexin 47 knockout

NIAID Data Ecosystem2026-03-10 收录

多发性硬化动物模型

胶质细胞功能研究

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121339 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2018-10-20

肠道微生物组与神经免疫

多发性硬化动物模型

IL-17A and IL-17F-producing CD4+ T cells (TH17 cells) are implicated in the development of chronic inflammatory diseases, such as multiple sclerosis (MS) and its animal model, experimental autoimmune

NIAID Data Ecosystem90

Data_Sheet_1_Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation.PDF

多发性硬化动物模型

炎症机制

BackgroundActivated protein C (APC), a serine protease with antithrombotic effects, protects in animal models of ischemic stroke by suppressing inflammation and enhancing vascular integrity, angiogene

NIAID Data Ecosystem60

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology [14 months]

神经退行性机制

胶质细胞功能研究

GRN haploinsufficiency causes frontotemporal lobar degeneration and results in microglial hyperactivation, lysosomal dysfunction and TDP-43 deposition. To understand the contribution of microglial hyp

NIAID Data Ecosystem30

Next-generation sequencing analysis of microglia from AD and Calhm2 cKO/AD mice

阿尔茨海默病基因表达

胶质细胞功能研究

To analyze the different genes in microglial Calhm2 cKO in normal and AD conditions. Microglial cells from 4 groups 6-month-old mice: WT mice, Calhm2 cKO mice, AT/AD mice and Calhm2 cKO/AD mice.

NIAID Data Ecosystem70

Single cell RNA-seq identifies a unique microglia type associated with Alzheimer’s disease [ChIP]

单细胞神经退行性疾病

胶质细胞功能研究

Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective treatments. Due to cellular heterogeneity, the roles of immune cell subsets in AD onset and progression are poorly

NIAID Data Ecosystem40

A novel animal model for secondary progressive multiple sclerosis by oligodendroglia-specific conditional connexin 47 knockout

资源简介：

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