Haplogroup distribution of 52 Chinese LHON subjects with m.14484T>C.

aThe Han Chinese from general populations were taken from published sources ([36], [37] and references therein). bThe Fisher exact test (two-tailed) was performed to discern the frequency difference of certain haplogroup between the LHON subjects (N = 52) and Han Chinese from the general populations (N = 408). cOnly mtDNAs belonging to R9b and R9c were considered here, mtDNAs belonging to haplogroup F were not included. dThose haplogroups that were not observed in the LHON patients but in reported Han Chinese were grouped together.