Development of Diamidophosphite Ligands and Their Application to the Palladium-Catalyzed Vinyl-Substituted Trimethylenemethane Asymmetric [3 + 2] Cycloaddition
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https://figshare.com/articles/dataset/Development_of_Diamidophosphite_Ligands_and_Their_Application_to_the_Palladium_Catalyzed_Vinyl_Substituted_Trimethylenemethane_Asymmetric_3_2_Cycloaddition/2504500
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资源简介：
A palladium-catalyzed asymmetric [3 + 2] cycloaddition
of a vinyl-substituted
trimethylenemethane (TMM) donor with α,β-unsaturated acyl
imidazoles is described. A newly designed bisdiamidophosphite ligand
derived from (S,S)-trans-1,2-cyclohexanediamine and (2R,4R)-pentanediol has been instrumental for the development of this process.
This transformation generates tetrasubstituted cyclopentanes bearing
three contiguous stereocenters in high yields, with good diastereo-
and enantioselectivity.
创建时间：
2016-02-20
