Degree of improvement of parameters assessing the wellbeing and the quality of life associated with treatment with levothyroxine (group 2) or levothyroxine and progestogens or GH (group 3).

To assess changes associated with treatment, a 3- (-1, 0, 1) or 5-point rating scale (-2, -1, 0, 1, 2) was used (-2 = lot worse, -1 = little worse, 0 = no change, 1 = little better, 2 = much better). Comparison between groups was performed by using Wilcoxon-rank-sum test or t-test.