Mean pooled differences in total effects and costs at 6 months follow-up and results of cost-effectiveness and cost-utility analyses after 6 months follow-up for the main analysis and for the sensitivity analyses.

*Models with costs as dependent variable adjusted for gender, costs in the previous three months and baseline severity of depression. Models with adherence as dependent variable adjusted for gender and age. Models with reduction of symptoms (50% or over reduction in PHQ-9) as dependent variable adjusted for gender, comorbidities and presence of major depression. Models with quality adjusted life years (QALY) as dependent variable adjusted for gender, age and baseline quality of life.