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Optimized precise base editing restores normal hearing in adult DFNB9 mice

NIAID Data Ecosystem2026-05-02 收录

耳聋基因治疗

碱基编辑技术

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1202654 数据链接链接失效反馈

官方服务：

资源简介：

NGS data of cell treated with Nme2ABE tools with otof-sgRNA.

应用场景：

创建时间：

2024-12-24

耳聋基因治疗

腺相关病毒载体

Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf subjects relies on direct stimulation of the auditory nerve through cochlear implants. Howev

NIAID Data Ecosystem70

C to G base editing in rice, tomato and poplar

转基因植物基因组

碱基编辑技术

C to G base editing in rice, tomato and poplar

NIAID Data Ecosystem40

Base editing in human cells with monomeric DddA-TALE fusion deaminases

碱基编辑技术

线粒体测序

NGS data of targeted deep sequencing and whole mitochondrial DNA sequencing

NIAID Data Ecosystem30

The Generation of Isogenic Single and Multiplex Gene Knockout Mice by Base Editing-Induced STOP

基因编辑动物

碱基编辑技术

Although CRISPR/Cas9 has been widely used to generate knockout mice, two major limitations remain: the founders usually carry a mixture of genotypes, and mosaicism harboring multiple genotypes. Theref

NIAID Data Ecosystem40

A base editor facilitates simultaneous purine and pyrimidine substitutions

碱基编辑技术

基因组工程

We have developed the ACGBEmax system, which is created by fusing a dual-functional deaminase, an engineered N-methylpurine DNA glycosylase, and an evolved SRAP domain with nCas9 (D10A). This system e

NIAID Data Ecosystem30

Optimized precise base editing restores normal hearing in adult DFNB9 mice

资源简介：

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