Toxic Effect of DOPAL on Substantia Nigra Neurons.

Means (SD); n.s.  =  not significant.The effect of DOPAL injections into the substantia nigra on neurons in either the pars compacta (SNpc) or the pars reticularis (SNpr) are shown. Control animals were injected with buffered saline while experimental animals were injected with DOPAL (4 µg/800 nl). Unbiased stereology was used to assess the number of neurons (see Methods).

本研究展示了多巴胺类似物（DOPAL）注入黑质（substantia nigra）对紧凑部（pars compacta, SNpc）或网状部（pars reticularis, SNpr）神经元的影响。对照组动物接受缓冲盐水注射，而实验组动物接受DOPAL（4 µg/800 nl）注射。本研究采用无偏的立体学方法评估神经元数量（详见方法部分）。