PREVENTABLE SERIOUS DRUG-DISEASE INTERACTIONS of RESERVE ANTIBIOTICS

Antibiotics that are used exclusively in hospital settings and reserved for treating infections caused by multidrug-resistant or extended-resistant bacterial pathogens are referred to as ‘reserved’ antibiotics. The purpose of this review article is to provide a better understanding of the risks associated with serious interactions between reserved antibiotics and various diseases, as well as to present key strategies for their prevention. The literature search was conducted in the MEDLINE, SCOPUS, EBSCO, and GOOGLE SCHOLAR databases without any restrictions on time or language. Only clinical studies, observational human studies, case reports, and case series that reported serious drug-disease interactions were considered. Knowledge of the interactions between reserve antibiotics and diseases, that have actually occurred and then been described in the medical literature, is crucial to the safe treatment of critically ill patients with infections caused by multidrug-resistant bacterial strains. Introducing into routine practice the checking of possible interactions with diseases that a patient suffers from, strict monitoring of changes in the function of the excretory organs (kidneys and liver), and measuring the concentration of drugs in the plasma will reduce the possibility of adverse drug-disease interactions.