Phenotypic metabotype differences between males and females of the discovery set (KORA F4) and the replication study (KORA F3).

P-values were calculated by a linear regression model with metabolites as dependent variable and sex as explanatory variable adjusted for age and BMI. Presented is a set of results of highly significant metabolite concentration differences between males and females of each metabolite subclass out of the 131 tested metabolites. A full list of results for all metabolites and additional information on the complete metabolite panel is provided as supplementary data (Table S2 and S3). Significance level after Bonferroni-correction is p-value  =  3.8×10-4.
C5  =  valerylcarnitine, C0  =  carnitine, C18  =  octadecanoylcarnitine, xLeu  =  isoleucine+leucine, Val  =  valerine, Gly = glycine, PC aa Cx∶y  =  phosphatidylcholine diacyl x∶y, PC ae Cx∶y  =  phosphatidylcholine acyl-akyl Cx∶y, LysoPC a Cx∶y  =  lysophosphatidylcholine acyl Cx∶y, SM (OH) Cx∶y  =  hydroxyshingomyeline Cx∶y, SM Cx∶y  =  shingomyelin Cx∶y; ß  =  beta-estimate of linear regression, r2  =  explained variance.