EPI-Clone dataset X.2: EPI-Clone + Mitochondrial mutation profiling from PBMCs of a healthy donor

This is a dataset supporting the EPI-Clone manuscript: Targeted single cell methylation profiling of PBMCs was performed with the scTAMseq method.Dataset is an R Data File (RDA) with two Seurat objects, created by the EPI-Clone algorithm. all_cells : EPI-Clone run on all cells, T_Cells: EPI-Clone run on T cells only.<b>ASSAYS:</b>AB: Antibody expression dataDNAm: DNA methylation data, containing binary observations (0: amplicon not observed, i.e. dropout or absence of DNA methylation, 1: amplicon observed, i.e. DNA methylation). See the paper on scTAMseq<b>DIMENSIONALITY REDUCTION</b>methPCA, methUMAP, protPCA, protUMAP: PCA and UMAP performed on methylation and surface protein data, respectivelyclonePCA, cloneUMAP: PCA and UMAP computed by EPI-Clone on static CpGs.<b>METADATA</b>CHOIR_clusters_0.05 : EPI-Clone IDphenotype: Cell type annotationchrM...: Genotyping of mitochondrial variants. ref refers to reads supporting the reference allele, alt to reads supporting the alternative allele, and ratio to the comuted heteroplasmy. Coordinates are hg19. Coordinates in the manuscriopt are hg38, for compatibiltiy with https://www.biorxiv.org/content/10.1101/2023.04.23.537997v1