Age-related neurodegenerative diseases (NDDs) and neuronal dysfunction are associated with the aggregation and propagation of specific pathogenic protein species (e.g. AÃ, a-synuclein, tau). However,
The overwhelming amount of available genomic sequence variation information demands a streamlined approach to examine known pathogenic mutations of any given protein. Here we seek to outline a strateg
Variably protease-sensitive prionopathy (VPSPr) is a rare, atypical subtype of prion disease currently classified as sporadic. We performed exome sequencing and targeted sequencing of PRNP non-coding
Results of PrPSc IHC at the sites of inflammation are also shown. *PrPSc deposition was seen occurring only within newly formed lymphoid follicles, either adjacent or not to granulomatous inflammatory
