Effect of Lactation on Proteome of Milk Fat Globule Membrane of Laoshan Dairy Goat

We have investigated MFGM proteome of goat milk at 1, 3, 30, 90, 150, and 240 d using data-independent acquisition and data-dependent acquisition quantitative proteomics approaches. The clustering and principal component analysis revealed that the protein components in goat milk was associated with specific lactation stages. Protein-protein interaction showed that albumin had more interaction with other proteins and was considered as a central node. Our results can provide a better understanding of the MFGM proteome during the lactation cycle of dairy goats and indicate changed proteins are important for the better understanding of intrinsic physiological function of goats.