A multiply redundant genetic switch locks in the transcriptional signature of T regulatory cells

ChEBI2012-08-23 更新2026-07-21 收录

细胞转录调控

免疫细胞分子机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-40278 数据链接链接失效反馈

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A multiply redundant genetic switch locks in the transcriptional signature of T regulatory cells

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2012-08-23

Selective expression of the transcription elongation factor Eleven Nineteen Lysine-rich Leukemia 3 (ELL3) in actiavted B lymphocytes drives rapid B cell proliferation. Homo sapiens

细胞转录调控

多发性骨髓瘤分子机制

To identify novel targets of the transcriptional repressor that functions to extinguish the B cell phenotype during terminal plasma cell differentiation, we assessed PRDM1 bound sequences through ChIP

NIAID Data Ecosystem70

Transcriptional changes after overexpression of proliferation drivers in human mammary epithelial cells.. Transcriptional changes after overexpression of proliferation drivers in human mammary epithelial cells.

乳腺肿瘤基因组学

细胞转录调控

Genomics has provided a detailed structural description of the cancer genome. Identifying oncogenic drivers that work primarily through dosage changes is a current challenge. Unrestrained proliferatio

NIAID Data Ecosystem70

Transcriptional activation by LR1 at the Eµ enhancer and switch region sites

免疫球蛋白类别转换重组

细胞转录调控

LR1 is a B cell-specific, sequence-specific duplex DNA binding activity which is induced in B cells carrying out class switch recombination. Here we identify several properties of LR1 which enable it

PubMed Central2000-07-15 更新60

RORɣt and RORα Signature Genes in Human Th17 Cells. Homo sapiens

细胞转录调控

免疫基因组学

In an effort to study gene expression modulated by RORɣt and RORα in human Th17 cells, global gene expression of human CD4 T cells activated under Th17 skewing conditions was profiled by RNA sequencin

NIAID Data Ecosystem70

Signature of human hepatocytes treated with Aroclor1254. Homo sapiens

毒理基因组学

细胞转录调控

In order to determine molecular rules for transcriptional regulation of targeted genes to explain in part the pleiotropic effect observed in animals and humans upon exposure to Aroclor 1254 we treated

NIAID Data Ecosystem70

A multiply redundant genetic switch locks in the transcriptional signature of T regulatory cells

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