Li2008 - Caulobacter Cell Cycle

This a model from the article:
A Quantitative Study of the Division Cycle of Caulobacter crescentus Stalked Cells.

Shenghua Li, Paul Brazhnik, Bruno Sobral, John J. Tyson PLoS Comput Biol
2008 Jan 25:4(1): e9 18225942
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Abstract:

Progression of a cell through the division cycle is tightly controlled at different steps to ensure the integrity of genome
replication and partitioning to daughter cells. From published experimental evidence, we propose a molecular
mechanism for control of the cell division cycle in Caulobacter crescentus. The mechanism, which is based on the
synthesis and degradation of three ‘‘master regulator’’ proteins (CtrA, GcrA, and DnaA), is converted into a quantitative
model, in order to study the temporal dynamics of these and other cell cycle proteins. The model accounts for
important details of the physiology, biochemistry, and genetics of cell cycle control in stalked C. crescentus cell. It
reproduces protein time courses in wild-type cells, mimics correctly the phenotypes of many mutant strains, and
predicts the phenotypes of currently uncharacterized mutants. Since many of the proteins involved in regulating the
cell cycle of C. crescentus are conserved among many genera of a-proteobacteria, the proposed mechanism may be
applicable to other species of importance in agriculture and medicine.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.