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Genome-wide survey of templated mutations in human rearranged heavy chain sequences

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NIAID Data Ecosystem2026-03-13 收录
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The goal of these studies was to implement a novel computational script, TRACE, that allows for detection of templated mutations in somatically mutated heavy-chain antibody sequences. Sequences were obtained from four individuals and were isolated from either memory B cell or circulating antibody secreting cell (ASC) populations. These studies aim to identify the contribution of the larger genome to somatic diversification of antibody sequences.

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2021-12-04
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