Salmonella enterica subsp. enterica serovar Paratyphi A Raw sequence reads

Salmonella enterica serovar Paratyphi A (S. Para A), is a causative agent of Paratyphoid fever. Unlike other endemic countries, multidrug resistance (MDR) in S. Paratyphi A strains is already reported from Pakistan. However, ceftriaxone resistance has not been reported from Pakistan. Here, we are reporting isolation of a ceftriaxone resistant S. Para A from a blood culture sample of a clinically suspected case of enteric fever. In this project we are submitting whole genome sequencings (WGS) of seven Salmonella enterica species isolates from enteric fever cases of Pakistan. Of these seven isolates three belongs to Salmonella enterica serovar Paratyphi A (S. Para A) and four belong to Salmonella enterica serovar Typhi (S. Typhi). Amomg S. Para A isolates. S7 was phenotypically resistant to ceftriaxone, cefixime, Ampicillin and Ciprofloxacin while susceptible to Chloramphenicol and Trimethoprim-Sulfamethoxazole. The other two S. Para A were found intermediately resistant to Ciprofloxacin only. Amongst S. Typhi isolates, S2, S3 and S5 were MDR plus ciprofloxacin intermediate/resistant, also showing resistance to ceftriaxone and cefixime. S6 was a MDR S. Typhi, susceptible to ceftriaxone, cefixime and intermediate resistant to Ciprofloxacin. All seven isolates were susceptible to azithromycin and Imipenem.