APOBEC3 promotes squamous differentiation and metastases via IL1A/AP-1 signaling

In urothelial carcinoma, up to 70% of mutations are caused by mutagenic activity of the APOBEC3 deaminases. To dissect the role of APOBEC3 in the progression of UC, we generated a mouse model UPPA with conditional knock out of Pten and Trp53 in addition to mouse Apobec3 (mA3) overexpression and scRNAseq was performed on the mouse bladder tumors. Overall design: UPPA and UPP mouse bladder tumors are anlyzed using scRNAseq human bladder tumor scRNAseq >>>Raw data for human samples are deposited in dbGaP due to patient privacy concerns<<<