Low Risk and High Risk Mouse Skin Carcinogenesis

Mouse skin carcinogenesis experiments suggest upon carcinogen treatment and promotion on mouse skin there arise at least two populations of tumors. One population has a higher incidence of progression from benign papilloma to a squamous cell carcinoma. Further studies have shown that a certain carcinogenesis protocol can select for these high risk tumors. These microarray experiments aim to reveal the genetic signatures of the low risk and high risk papilloma. Keywords: Genetic Signatures These experiments were designed on a common reference platform. Chips were hybridized with cDNA labeled with two fluoro markers. One labeled with Cy5 and the other Cy3 and one of the probes would be derived from Clontech's mouse universal reference RNA.