A Direct Approach to a 6‑Hetarylamino[1,2,4]triazolo[4,3‑<i>b</i>][1,2,4,5]tetrazine Library

The synthesis of 6-hetarylamino­[1,2,4]­triazolo­[4,3-b]­[1,2,4,5]­tetrazines is reported. The functionalized secondary amines were constructed via a K2CO3-mediated SNAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)­[1,2,4]­triazolo­[4,3-b]­[1,2,4,5]­tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded in good yields.