BCL2L11

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

该基因编码的蛋白质属于BCL-2蛋白家族。BCL-2家族成员可形成异源或同源二聚体，充当抗凋亡或促凋亡调节因子，参与多种细胞活动。该基因编码的蛋白质含有Bcl-2同源结构域3（BH3）。研究表明，该蛋白质能与BCL-2蛋白家族的其他成员相互作用，并作为凋亡激活剂发挥作用。该基因的表达可被神经生长因子（NGF）和forkhead转录因子FKHR-L1诱导，这表明该基因在神经元和淋巴细胞凋亡中发挥重要作用。小鼠同源基因的转基因研究提示，该基因在胸腺细胞阴性选择中作为凋亡的必要启动子发挥作用。该基因已鉴定出几种选择性剪接的转录变体。[由RefSeq提供，2013年6月]