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Genome-wide maps of PARP-1-bound nucleosomes (human). Homo sapiens

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NIAID Data Ecosystem2026-03-09 收录
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PARP-1 binds to specific nucleosomes to regulate gene activity. While PARP-1's role in transcription inititaion is known, a surprising finding here was that PARP-1 is highly enriched at exon-intron and intron-exon boundaries, sort of demarcting exons. Thius indicating a role in alternative splicing. Overall design: ChIP-seq of PARP-1-bound nucleosomes

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2014-09-30
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