The suppression of MAPK/NOX/MMP signaling prompts renoprotection conferred by prenatal naproxen in weaning preeclamptic rats

All raw data of the study entitled "The suppression of MAPK/NOX/MMP signaling prompts renoprotection conferred by prenatal naproxen in weaning preeclamptic rats". we tested the hypothesis that renal programming incited by preeclampsia is modulated by gestationally administration of nonsteroidal antiinflammatory drugs (NSAIDs). The data showed that naproxen was more advantageous than celecoxib or diclofenac in relieving functional and morphological manifestations of the erupted renal injury. Molecularly, the suppression of the upregulated offending signals of inflammatory (arachidonate-derived prostanoids, p-ERK2), oxidative (NOX2/4), fibrotic (MMP9), and autophagic (LC3) cascades provides a mechanistic basis for the privileged action of naproxen.