Response to Neoadjuvant Chemotherapy in Triple Negative Breast tumors.. Homo sapiens

In a cohort study of 7 women with primary invasive breast cancer, we obtained a tumor specimen before (biopsy) and after (tumorectomy) 4 cycles of NAC with epirubicine and cyclophosphamide, followed by 4 cycles of taxanes. Total RNA was extracted from tumor specimens and the whole transcriptome was quantified with Affymetrix HuGene1.1ST. Molecular functions changing during chemotherapy were searched. Overall design: Whole genome expression of triple negative breast cancer tissues were measured before and after four cycles neoadjuvant chemotherapy