File S1 - In Vivo Angiogenesis Screening and Mechanism of Action of Novel Tanshinone Derivatives Produced by One-Pot Combinatorial Modification of Natural Tanshinone Mixture from Salvia Miltiorrhiza

Supporting Information. Section 1. A Stack Plot Showing the HPLC Chromatograms of Compounds 1-11. Section 2. Detailed Discussion of the Structure Elucidation of New Derivatives. Section 3. Original Mass Spectra and NMR Spectra of Compounds 1-11. Section 4. Table S1. Crystal data and structure refinement for compounds 1, 2, 3, 6 and 10. Section 5. Structural Formulae of Natural Parental Tanshinones 1a-11a. Section 6. Configurations of Natural Parental Tanshinones 1a-11a. Section 7. Table S2. The EC50 and IC50 values of compounds 3, 10, Tan IIA, CPT and Tan I in VRI-treated zebrafish. Section 8. Effects of Compound 10 on the Proliferation, Migration and Invasion of HUVECs. (DOCX)