five

Sequencing of hDMD gene in hDMDdel52/mdx mouse

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https://www.ncbi.nlm.nih.gov/sra/SRP259884
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hDMDdel52/mdx mouse is a mouse model which is used for Duchenne muscular dystrophy researches. It harbors full length human DMD gene with exon 52 deletion and allows testing of human specific antisense oligonucleotides in mouse for dystrophin restoration studies. During routine experiments, unexpected genetic rearrangements was found in this mouse model. To elucidate this, Oxford Nanopore long read massive parallel sequencing was performed.
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2020-05-06
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