A method is described for monitoring the enzyme-mediated unwinding of duplex DNA spectrophotometrically. The assay employs a partially duplex oligonucleotide substrate modified at the complementary en

PubMed Central1994-06-07 更新30

Supplementary Table S1 from Small Molecule–Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1

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药物靶点活性测定

Protein kinase inhibition profile for 1. Compound 1 was tested against a panel of 342 kinases at a single dose concentration of 20 μM. Columns labeled 'Data 1' and 'Data 2' indicate data from technica

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Activity comparison for TBK1 and IKKε.

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药物发现

Number of active compounds (N) detected in each screen for total number detected (unfiltered), number after drug like filtering (filtered.drug-like), hits from the LOPAC and Kinase libraries, and the

NIAID Data Ecosystem50

Curve class distribution of small molecules from the kinase inhibitor-enriched library screen.

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分子活性分析

Curve class distribution of small molecules from the kinase inhibitor-enriched library screen.

Figshare2023-08-04 更新10