ROR?t and RORa Signature Genes in Human Th17 Cells
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In an effort to study gene expression modulated by ROR?t and RORa in human Th17 cells, global gene expression of human CD4 T cells activated under Th17 skewing conditions was profiled by RNA sequencing. ROR?t and RORa signature genes were identified in these Th17 cells treated with specific siRNAs to knock down ROR?t or RORa expression. In addition, selective small molecule ROR?t modulators were also utilized as pharmacological tools in ROR?t signature gene identification.
创建时间：
2017-10-10
