Relative risks of death for the ApoE4 allele carriers compared to the non-carriers in the selected age groups of the genotyped participants of the FHS original, FHSO, and LLFS cohorts.

RR = relative risk; CI = Confidence interval; Ntotal and Ndied denote the total number of genotyped individuals and the number of deaths among them, respectively.All models were adjusted for birth cohorts measured as a continuous variable except the model for long-living men and women from the LLFS parental generation (LLFS_P) denoted by asterisk (*). Models for pooled samples in the FHS (i.e., the FHS original and FHSO cohorts; denoted as FHS+FHSO) and LLFS (i.e., the LLFS offspring and spouses; denoted as LLFS_O+S) were adjusted for potential cohort differences. Models for the LLFS were also adjusted for potential field center differences.“All” in column “Age group” denotes the sample of all ages; other notations in this column indicate the range of ages at death or the end of follow up in each sample. For example, “≥70” implies a group of individuals who died at 70+ years or was aged 70+ years at the end of follow up.