Porcine Macrophage Whole Transcriptome Sequencing underlying Antiviral Regulation

Previous studies showed that interferon-mediated antiviral activity is subtype-dependent. Using a whole transcriptome procedure, we targeted to characterize the small RNA transcriptome (sRNA-Seq) and especially differential microRNA (miRNA) responses in porcine alveolar macrophages (PAMs) upon antiviral activation by viral infection and interferon (IFN) stimulation. This study provides a general picture of porcine sRNA composition and pinpoints key SEMs underlying antiviral regulation in PAMs correlated to a typical respiratory RNA virus in pigs