Diabetes Mellitus Type 1 miRnome. Diabetes Mellitus Type 1 miRnome

Several microRNAs (miRNAs) have been reported in association with autoimmune diseases, including type 1 diabetes (T1DM). Therefore, we performed the miRNome of T1DM samples and investigated important pathways that these miRNAs are involved, considering both nuclear and mitochondrial functions. High throughput small RNA-sequencing was conducted in T1DM patients and control individuals. 41 miRNAs were found to be dysregulated in T1DM patients compared to control, suggesting a potential role these miRNAs in T1DM development. Functional analysis revealed that 14 DE miRNAs target mitochondrial genes, and 31 DE miRNAs target nuclear genes involved in the mitochondrial metabolism, the most of them participating of the transcription (nuclear), apoptosis and mitochondrial signaling.