Comparative effectiveness of atorvastatin (10 mg) versus simvastatin (20 mg).

The analyses included initiators between January 1998 and June 2006 in Finland. Hazard ratios for a composite of cardiovascular events1 were estimated with different Cox proportional hazard regression models.HR = hazard ratio; CI = confidence interval; PS = propensity score.1Cardiovascular events; hospitalized acute myocardial infarction ischemic cardiac disease (ICD-10 codes I20–I24), percutaneous coronary intervention or coronary artery bypass surgery, and stroke (I63, I64).2Adjusted for all covariates included in the propensity scores, including the period.3Period included in the propensity score. Matching within the whole cohort within a 0.01 caliber.4Adjusted for the covariates strongly associated with the outcome.5Matching conducted within each of the 17 six-month periods since January 1998.