Catalytic Asymmetric Construction of Chiral Hydropyridazines via Conjugate Addition of N‑Monosubstituted Hydrazones to Enones
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The first example of a highly enantioselective and scalable formal diaza–ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines.
创建时间：
2016-02-18
