Figure S1 - Ascorbic Acid Has Superior Ex Vivo Antiproliferative, Cell Death-Inducing and Immunomodulatory Effects over IFN-α in HTLV-1-Associated Myelopathy

High-dose AA exerts broad antiproliferative effects in both NDs and HAM/TSP PBMCs. NDs PBMCs (n = 4) and HAM/TSP PBMCs (n = 3) were treated for 5 days with anti-CD3 monoclonal antibody (0.2 µg/ml) in the absence or presence of high-dose AA (100 µg/ml), performed in triplicate. Thymidine incorporation is expressed as percent of control (untreated cells) and shown in the y-axis, whereas the treatment conditions are shown in the x-axis. The one-sample t-test p-values are indicated by asterisks (****** (EPS)