Observing intermediate substrate states during an enzymatic process: a combin...

The specific recognition, unfolding and degradation of faulty proteins is an essential process in all living cells to guarantee protein homoeostasis and keep the proteome in a...异常蛋白质的特异性识别、解折叠与降解，是所有活细胞中保障蛋白质稳态（protein homoeostasis）、维持蛋白质组（proteome）处于……的必要过程。